神经元特异性烯醇化酶是急性神经元损伤的标志物，在复杂部分性癫痫持续状态中会升高。

Neuron-specific enolase, a marker of acute neuronal injury, is increased in complex partial status epilepticus.

作者信息

DeGiorgio C M, Gott P S, Rabinowicz A L, Heck C N, Smith T D, Correale J D

机构信息

Department of Neurology, University of Southern California School of Medicine, Los Angeles 90033, USA.

出版信息

Epilepsia. 1996 Jul;37(7):606-9. doi: 10.1111/j.1528-1157.1996.tb00623.x.

DOI:10.1111/j.1528-1157.1996.tb00623.x

PMID:8681891

Abstract

PURPOSE

To determine whether complex partial status epilepticus (CPSE) causes brain injury in humans. Serum neuron-specific enolase (s-NSE) is an accepted marker of acute brain injury, and increases in s-NSE have been correlated with the duration and outcome of generalized convulsive status epilepticus. s-NSE levels in CPSE are unknown. Increase in s-NSE in CPSE would provide new information about the degree of brain injury in CPSE and would help confirm that CPSE is a medical emergency.

METHODS

This was a pilot prospective study of serial levels of s-NSE and outcome in CPSE. Eight patients with confirmed CPSE and no acute neurologic deficit were identified prospectively. Results were compared with those of normal and epileptic control groups, and outcome was assessed at hospital discharge or at 7 days with the Glasgow Oucome Scale (GOS).

RESULTS

The mean peak s-NSE was 21.81 ng/ml, which for the 8 patients with CPSE was four times higher than that of normal controls (mean s-NSE = 5.36 SD = 1.66, p = 0.0003) and epileptic controls (mean s-NSE = 4.61 SD = 1.74, p. = 0.001).

CONCLUSION

The increase in s-NSE provides new evidence that CPSE causes brain injury in humans.

摘要

目的

确定复杂部分性癫痫持续状态（CPSE）是否会导致人类脑损伤。血清神经元特异性烯醇化酶（s-NSE）是公认的急性脑损伤标志物，s-NSE的升高与全身惊厥性癫痫持续状态的持续时间和预后相关。CPSE患者的s-NSE水平尚不清楚。CPSE患者s-NSE升高将为CPSE脑损伤程度提供新信息，并有助于证实CPSE是一种医疗急症。