DeGiorgio C M, Gott P S, Rabinowicz A L, Heck C N, Smith T D, Correale J D
Department of Neurology, University of Southern California School of Medicine, Los Angeles 90033, USA.
Epilepsia. 1996 Jul;37(7):606-9. doi: 10.1111/j.1528-1157.1996.tb00623.x.
To determine whether complex partial status epilepticus (CPSE) causes brain injury in humans. Serum neuron-specific enolase (s-NSE) is an accepted marker of acute brain injury, and increases in s-NSE have been correlated with the duration and outcome of generalized convulsive status epilepticus. s-NSE levels in CPSE are unknown. Increase in s-NSE in CPSE would provide new information about the degree of brain injury in CPSE and would help confirm that CPSE is a medical emergency.
This was a pilot prospective study of serial levels of s-NSE and outcome in CPSE. Eight patients with confirmed CPSE and no acute neurologic deficit were identified prospectively. Results were compared with those of normal and epileptic control groups, and outcome was assessed at hospital discharge or at 7 days with the Glasgow Oucome Scale (GOS).
The mean peak s-NSE was 21.81 ng/ml, which for the 8 patients with CPSE was four times higher than that of normal controls (mean s-NSE = 5.36 SD = 1.66, p = 0.0003) and epileptic controls (mean s-NSE = 4.61 SD = 1.74, p. = 0.001).
The increase in s-NSE provides new evidence that CPSE causes brain injury in humans.
确定复杂部分性癫痫持续状态（CPSE）是否会导致人类脑损伤。血清神经元特异性烯醇化酶（s-NSE）是公认的急性脑损伤标志物，s-NSE的升高与全身惊厥性癫痫持续状态的持续时间和预后相关。CPSE患者的s-NSE水平尚不清楚。CPSE患者s-NSE升高将为CPSE脑损伤程度提供新信息，并有助于证实CPSE是一种医疗急症。
这是一项关于CPSE患者s-NSE系列水平及预后的前瞻性初步研究。前瞻性确定了8例确诊为CPSE且无急性神经功能缺损的患者。将结果与正常对照组和癫痫对照组进行比较，并在出院时或7天时采用格拉斯哥预后量表（GOS）评估预后。
s-NSE平均峰值为21.81 ng/ml，8例CPSE患者的该值是正常对照组（s-NSE均值=5.36，标准差=1.66，p=0.0003）和癫痫对照组（s-NSE均值=4.61，标准差=1.74，p=0.001）的4倍。
s-NSE升高提供了新的证据，证明CPSE会导致人类脑损伤。
