育亨宾对大鼠促肾上腺皮质激素诱导的行为综合征的影响。

Influence of yohimbine on the ACTH-induced behavioural syndrome, in rats.

作者信息

Poggioli R, Vergoni A V, Bertolini A

出版信息

Pharmacol Res Commun. 1985 Jul;17(7):671-8. doi: 10.1016/0031-6989(85)90074-8.

Abstract

In adult male rats, yohimbine at low doses (0.1, 0.5 and 1 mg/kg i.p.) potentiated, and at high doses (30.0 mg/Kg) antagonized, the behavioural syndrome induced by the intracerebroventricular injection of ACTH 1-24 (3 micrograms/rat) (stretching-yawning syndrome and penile erections). These results support the hypothesis that brain catecholaminergic systems play a positive role in the ACTH-induced behavioural syndrome.

摘要

在成年雄性大鼠中，低剂量（0.1、0.5和1毫克/千克腹腔注射）的育亨宾可增强，而高剂量（30.0毫克/千克）则拮抗脑室内注射促肾上腺皮质激素1-24（3微克/大鼠）诱导的行为综合征（伸展-打哈欠综合征和阴茎勃起）。这些结果支持了脑儿茶酚胺能系统在促肾上腺皮质激素诱导的行为综合征中起积极作用的假说。