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4
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新型2-吡啶酮抗菌剂A-86719.1的体外活性

In vitro activity of A-86719.1, a novel 2-pyridone antimicrobial agent.

作者信息

Eliopoulos G M, Wennersten C B, Cole G, Chu D, Pizzuti D, Moellering R C

机构信息

Department of Medicine, Deaconess Hospital, Boston, Massachusetts 02215, USA.

出版信息

Antimicrob Agents Chemother. 1995 Apr;39(4):850-3. doi: 10.1128/AAC.39.4.850.

DOI:10.1128/AAC.39.4.850
PMID:7785983
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC162641/
Abstract

This study evaluated the in vitro activity of A-86719.1, a novel 2-pyridone antimicrobial agent. The drug inhibited all tested members of the family Enterobacteriaceae at < or = 0.5 microgram/ml and all tested Pseudomonas aeruginosa, Burkholderia (Pseudomonas) cepacia, and Xanthomonas maltophilia strains at < or = 2 micrograms/ml. All but two strains of gram-positive bacteria were inhibited by < or = 1 microgram of the new drug per ml, including isolates highly resistant to ciprofloxacin.

摘要

本研究评估了新型2-吡啶酮抗菌剂A-86719.1的体外活性。该药物对肠杆菌科所有测试菌的抑制浓度≤0.5微克/毫升，对所有测试的铜绿假单胞菌、洋葱伯克霍尔德菌（假单胞菌属）和嗜麦芽窄食单胞菌菌株的抑制浓度≤2微克/毫升。每毫升≤1微克的新药可抑制除两株外的所有革兰氏阳性菌，包括对环丙沙星高度耐药的分离株。