Iwagaki H, Hizuta A, Tanaka N, Orita K
First Department of Surgery, Okayama University Medical School, Japan.
Immunol Invest. 1995 Mar;24(3):479-87. doi: 10.3109/08820139509066844.
Neopterin (NPT), a pteridine intermediate metabolite in the biopterine synthetic pathway, is synthesized and secreted by monocytes/macrophages upon stimulation, mainly by gamma-interferon produced by activated T cells. C-reactive protein (CRP) is one of the major acute-phase reactants and its release is thought to be mediated by interleukin-6. Plasma concentrations of NPT and CRP were synchronously analyzed in 25 determinations of 5 patients with severe infectious complications and 50 determinations of 10 cancer-burden patients representing cachexia. The mean value of NPT (pmol/ml) was 201.6 in the infection group and 16.5 in the cancer cachexia group. The mean value of CRP (mg/dl) was 12.5 in the infection group and 3.4 in the cancer cachexia group. The number of samples in which NPT alone exceeded the cut-off level were 0/25 (0%) in the infection group and 38/50 (76.0%) in the cancer cachexia group. The number of samples in which both NPT and CRP exceeded the cut-off level was 25/25 (100%) in the infection group and 12/50 (24.0%) in the cancer cachexia group. The mean ratio of NPT to CRP was 11.3 in the infection group and 30.7 in the cancer cachexia group, respectively. These results suggest that gamma-interferon could play the principal role in the pathogenesis of cancer cachexia and that interleukin-6 modified the disease status. Interleukin-6 would be the critical mediator of host responses in infectious complications.
新蝶呤（NPT）是生物蝶呤合成途径中的一种蝶啶中间代谢产物，在受到刺激时由单核细胞/巨噬细胞合成并分泌，主要是由活化T细胞产生的γ-干扰素所介导。C反应蛋白（CRP）是主要的急性期反应物之一，其释放被认为是由白细胞介素-6介导的。对5例患有严重感染并发症的患者进行了25次测定，对10例代表恶病质的癌症患者进行了50次测定，同步分析了血浆中NPT和CRP的浓度。感染组NPT的平均值（pmol/ml）为201.6，癌症恶病质组为16.5。感染组CRP的平均值（mg/dl）为12.5，癌症恶病质组为3.4。在感染组中，仅NPT超过临界值的样本数为0/25（0%），在癌症恶病质组中为38/50（76.0%）。NPT和CRP均超过临界值的样本数在感染组中为25/25（100%），在癌症恶病质组中为12/50（24.0%）。感染组NPT与CRP的平均比值分别为11.3，癌症恶病质组为30.7。这些结果表明，γ-干扰素可能在癌症恶病质的发病机制中起主要作用，白细胞介素-6改变了疾病状态。白细胞介素-6将是感染并发症中宿主反应的关键介质。
