Lövestad A, Sabel G, Stefansson M, Gästrin B, Lundström R
Scand J Infect Dis Suppl. 1976(8):58-60.
The clinical efficacies of co-trimoxazole and nitrofurantoin were compared in patients with urinary-tract infections associated with significant bacteriuria with coliform bacteria tested and found to be sensitive to both drugs. Of 27 patients treated with co-trimoxazole, 23 were cured after 10 days' treatment with 320 mg trimethoprim and 1600 mg sulphamethoxazole daily (85%). Of 18 patients treated with nitrofurantoin (200 mg/day for 10 days), 7 were cured (39%). Thus, cotrimoxazole was significantly superior (p less than 0.01) in this study. A significant (p less than 0.001) but temporary and modest rise of the serum-creatinine levels was noted after 5 days' treatment with co-trimoxazole. Such a rise was not observed in the nitrofurantoin group. Only a few minor side effects were noted in both groups.
对患有与大量菌尿相关的尿路感染且所检测的大肠埃希菌对复方新诺明和呋喃妥因均敏感的患者，比较了这两种药物的临床疗效。在27例接受复方新诺明治疗的患者中，23例在每日服用320毫克甲氧苄啶和1600毫克磺胺甲恶唑治疗10天后治愈（85%）。在18例接受呋喃妥因治疗的患者中（200毫克/天，共10天），7例治愈（39%）。因此，在本研究中复方新诺明明显更优（p小于0.01）。在用复方新诺明治疗5天后，观察到血清肌酐水平显著（p小于0.001）但短暂且轻微升高。在呋喃妥因组未观察到这种升高。两组均仅记录到少数轻微副作用。
