志贺毒素相关溶血尿毒综合征：丁酸钠对人脐静脉内皮细胞对志贺毒素敏感性的影响
Shiga toxin-associated hemolytic uremic syndrome: effect of sodium butyrate on sensitivity of human umbilical vein endothelial cells to Shiga toxin.
作者信息
Louise C B, Kaye S A, Boyd B, Lingwood C A, Obrig T G
机构信息
Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, New York 14642, USA.
出版信息
Infect Immun. 1995 Jul;63(7):2766-9. doi: 10.1128/iai.63.7.2766-2769.1995.
Abstract
Escherichia coli O157:H7-related vascular damage such as hemolytic uremic syndrome is believed to require the Shiga-like toxins. This study demonstrated that sodium butyrate sensitized human umbilical vein endothelial cells to Shiga toxin and increased the expression of Shiga toxin receptor, globotriaosylceramide (Gb3), on human umbilical vein endothelial cells.
摘要
诸如溶血尿毒综合征之类的与大肠杆菌O157:H7相关的血管损伤被认为需要志贺样毒素。本研究表明，丁酸钠使人类脐静脉内皮细胞对志贺毒素敏感，并增加了人类脐静脉内皮细胞上志贺毒素受体——球三糖神经酰胺（Gb3）的表达。
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