Deicken R F, Weiner M W, Fein G
Magnetic Resonance Unit, VA Medical Center, San Francisco, CA, USA.
J Affect Disord. 1995 Mar 14;33(3):195-9. doi: 10.1016/0165-0327(94)00089-r.
In vivo [31P]magnetic resonance spectroscopic imaging ([31P]MRSI) was performed on 12 unmedicated, euthymic bipolar patients and 14 control subjects to determine if there were alterations in high-energy P metabolism in the temporal lobes of bipolar patients. Compared with the control group, the patients with bipolar disorder demonstrated significantly lower phosphomonoesters (PME) in both the left and right temporal lobes. No other group differences in P metabolites or lateralized asymmetries were noted. This preliminary study provides support for altered temporal lobe phospholipid metabolism in bipolar disorder.
对12名未接受药物治疗、处于心境正常状态的双相情感障碍患者和14名对照者进行了体内[31P]磁共振波谱成像（[31P]MRSI），以确定双相情感障碍患者颞叶中的高能磷代谢是否存在改变。与对照组相比，双相情感障碍患者在左右颞叶中的磷酸单酯（PME）均显著降低。未发现磷代谢物或侧化不对称性方面的其他组间差异。这项初步研究为双相情感障碍中颞叶磷脂代谢改变提供了支持。
