Kato T, Shioiri T, Murashita J, Hamakawa H, Inubushi T, Takahashi S
Department of Psychiatry, Shiga University of Medical Science, Japan.
Psychiatry Res. 1994 Mar;55(1):41-50. doi: 10.1016/0925-4927(94)90010-8.
Phosphorus-31 magnetic resonance spectroscopy (31P-MRS) was used to examine whether reduced levels of phosphomonoesters (PME) were correlated with ventricular enlargement in 40 patients with bipolar disorder and 60 age-matched normal control subjects. Ventricular enlargement was assessed by magnetic resonance imaging (1H-MRI) using the following three methods: Evans ratio (ER), Huckman number (HN), and minimum distance of caudate nuclei (MDCN). Although MDCN and ER were significantly larger in the patient group, no significant correlations were found between 31P-MRS and 1H-MRI. PME was negatively correlated with age in bipolar disorder. Decreased levels of PME were found only in bipolar I disorder. Intracellular pH was positively correlated with duration of lithium treatment. These results suggest that the observed PME reduction was not related to ventricular enlargement, but the issue should be further studied with volumetric MRI analysis.
采用磷-31磁共振波谱法（31P-MRS）检测40例双相情感障碍患者和60例年龄匹配的正常对照者中磷酸单酯（PME）水平降低是否与心室扩大相关。使用以下三种方法通过磁共振成像（1H-MRI）评估心室扩大情况：埃文斯比率（ER）、赫克曼数（HN）和尾状核最小距离（MDCN）。虽然患者组的MDCN和ER明显更大，但在31P-MRS和1H-MRI之间未发现显著相关性。双相情感障碍中PME与年龄呈负相关。仅在双相I型障碍中发现PME水平降低。细胞内pH与锂治疗持续时间呈正相关。这些结果表明，观察到的PME降低与心室扩大无关，但该问题应通过容积MRI分析进一步研究。
