Kato T, Shioiri T, Murashita J, Hamakawa H, Takahashi Y, Inubushi T, Takahashi S
Department of Psychiatry, Shiga University of Medical Science, Japan.
Psychol Med. 1995 May;25(3):557-66. doi: 10.1017/s003329170003347x.
High energy phosphate metabolites were measured using phase-encoded in vivo phosphorus-31 magnetic resonance spectroscopy (31P-MRS) in both the left and right frontal lobes of 25 patients with bipolar disorder. Eleven patients were examined in the depressive state, 12 in the manic state, and 21 in the euthymic state. Twenty-one age-matched normal volunteers were also examined. The phosphocreatine (PCr) peak area percentage in the left frontal lobe in the patients in the depressive state was decreased compared with that in the normal controls. It was significantly negatively correlated with the Hamilton Rating Scale for Depression score evaluated at the time of 31P-MRS examination. The PCr peak area percentage in the right frontal lobe in the patients in the manic and the euthymic states was decreased compared with that in the controls. These results are compatible with previous reports describing reduction of glucose metabolism in the left frontal lobe in depressive patients with bipolar disorder and trait-dependent right hemisphere dysfunction in bipolar disorder.
使用相位编码体内磷-31磁共振波谱（31P-MRS）测量了25例双相情感障碍患者左、右额叶的高能磷酸代谢物。11例患者处于抑郁状态，12例处于躁狂状态，21例处于心境正常状态。还检查了21名年龄匹配的正常志愿者。与正常对照组相比，抑郁状态患者左额叶的磷酸肌酸（PCr）峰面积百分比降低。它与31P-MRS检查时评估的汉密尔顿抑郁量表评分呈显著负相关。与对照组相比，躁狂和心境正常状态患者右额叶的PCr峰面积百分比降低。这些结果与先前的报告一致，这些报告描述了双相情感障碍抑郁患者左额叶葡萄糖代谢降低以及双相情感障碍中依赖特质的右半球功能障碍。
