Kato T, Shioiri T, Murashita J, Hamakawa H, Inubushi T, Takahashi S
Department of Psychiatry, Shiga University of Medical Science, Japan.
Psychiatry Res. 1995 Sep 29;61(3):151-60. doi: 10.1016/0925-4927(95)02752-j.
Magnetic resonance spectroscopy (one-dimensional chemical shift imaging) was used to measure membrane phospholipid metabolism and high-energy phosphate metabolism in the left and right frontal lobes of 27 schizophrenic patients. In the schizophrenic patients, the phosphomonoester peak area was decreased in bilateral frontal lobes compared with that in age-matched normal subjects. On the other hand, the peak area of beta-adenosine triphosphate was increased in the left frontal lobe in the schizophrenic group. The phosphocreatine peak area was increased in the left frontal lobe of schizophrenic patients with high scores on the Scale for the Assessment of Negative Symptoms (SANS).
采用磁共振波谱法（一维化学位移成像）测量了27例精神分裂症患者左右额叶的膜磷脂代谢和高能磷酸代谢。与年龄匹配的正常受试者相比，精神分裂症患者双侧额叶的磷酸单酯峰面积减小。另一方面，精神分裂症组左侧额叶的β-三磷酸腺苷峰面积增加。在阴性症状评定量表（SANS）得分高的精神分裂症患者中，左侧额叶的磷酸肌酸峰面积增加。
