Belza B L
Department of Physiological Nursing, School of Nursing, University of Washington, Seattle 98195, USA.
J Rheumatol. 1995 Apr;22(4):639-43.
To compare self-reported fatigue in adults with rheumatoid arthritis (RA) with age and sex matched healthy controls without RA and to determine the relationships of fatigue to pain, sleep, functional status, depressive symptoms, and disease activity.
A sample of 51 patients with RA and 46 age and sex matched controls without RA completed self-administered questionnaires 3 times at 6-8 week intervals. Questionnaires included the Multidimensional Assessment of Fatigue scale, Sleep Survey, Health Assessment Questionnaire, and the Profile of Mood States. Patients had blood drawn for hematocrit (Hct) and C-reactive protein on the same day the questionnaires were completed.
Fatigue scores were significantly higher in persons with RA compared to healthy controls. Fatigue did not change significantly in either group over time. Fatigue was strongly associated with poor sleep, functional disability, greater pain, more depressive symptoms, and lower Hct.
The importance of assessing fatigue in RA is confirmed. Effective management is needed to control clinical manifestations of RA that were found to be strongly associated with fatigue such as poor sleep, functional disability, pain, depressive symptoms, and lower Hct.
比较类风湿关节炎（RA）成人患者与年龄和性别匹配的无RA健康对照者自我报告的疲劳情况，并确定疲劳与疼痛、睡眠、功能状态、抑郁症状及疾病活动度之间的关系。
51例RA患者和46例年龄和性别匹配的无RA对照者组成的样本，每隔6 - 8周完成3次自填式问卷。问卷包括疲劳多维评估量表、睡眠调查、健康评估问卷和情绪状态剖面图。患者在完成问卷当天抽取血液检测血细胞比容（Hct）和C反应蛋白。
与健康对照者相比，RA患者的疲劳评分显著更高。两组患者的疲劳程度随时间均无显著变化。疲劳与睡眠不佳、功能障碍、疼痛加剧、抑郁症状更多及Hct降低密切相关。
证实了评估RA患者疲劳情况的重要性。需要进行有效管理以控制RA的临床表现，这些表现被发现与疲劳密切相关，如睡眠不佳、功能障碍、疼痛、抑郁症状及Hct降低。
