异常黑素小体：黑素细胞异型性的超微结构标志物。
Abnormal melanosomes: ultrastructural markers of melanocytic atypia.
作者信息
Vicente Ortega V, Martínez Díaz F, Carrascosa Romero C, Ortuño Pacheco G
机构信息
Department of Pathology, University of Murcia, Spain.
出版信息
Ultrastruct Pathol. 1995 Mar-Apr;19(2):119-28. doi: 10.3109/01913129509014612.
To identify possible ultrastructural markers of melanocytic atypia, a quantitative ultrastructural study was made of melanocytes found at the dermal-epidermal boundary of normal skin and in benign, premalignant, and malignant melanocytic lesions. There was a significant increase (p < 0.05) in the number of melanosomes per melanocyte in the premalignant and malignant lesions compared with the number observed in the benign lesions. There was a significantly higher number (p < 0.05) of abnormal melanosomes (with irregularities in the laminar matrix or with a granular or clumpy matrix) in the premalignant and malignant lesions, which suggests that the presence of a high percentage of abnormal melanosomes might act as a useful ultrastructural marker in the diagnosis of melanocytic atypia.
为了确定黑素细胞异型性可能的超微结构标志物，对正常皮肤真皮 - 表皮交界处以及良性、癌前和恶性黑素细胞性病变中发现的黑素细胞进行了定量超微结构研究。与良性病变中观察到的黑素小体数量相比，癌前和恶性病变中每个黑素细胞的黑素小体数量显著增加（p < 0.05）。癌前和恶性病变中异常黑素小体（层状基质不规则或呈颗粒状或块状基质）的数量明显更高（p < 0.05），这表明高比例异常黑素小体的存在可能作为诊断黑素细胞异型性的有用超微结构标志物。
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