Davies I, O'Neill P A, McLean K A, Catania J, Bennett D
University of Manchester, Department of Geriatric Medicine, Withington Hospital.
Age Ageing. 1995 Mar;24(2):151-9. doi: 10.1093/ageing/24.2.151.
We have examined simultaneous changes in thirst, plasma osmolality and arginine vasopressin, after oral water loading or hypertonic saline infusion. The studies were carried out in the same subjects, comprising young controls aged 26.8 years (SD 4.8, n = 10) and health status-defined elderly people aged 72.1 years (SD 3.1, n = 10). Water loading caused significant falls in plasma osmolality (p < 0.001) and thirst (p < 0.001), but there was no variation with age. Infusion with 462 mmol/l of sodium chloride increased plasma osmolality significantly (p < 0.001), but there was no variation with age (p = 0.12). The perception of thirst during the osmotic loading experiment was recorded differently by the two age groups (p < 0.0001). However, linear regression analysis showed no age difference in the relationship between thirst and plasma osmolality during osmotic loading. During osmotic loading the relationship between the plasma concentration of arginine vasopressin in response to increasing plasma osmolality varied significantly (slope: p = 0.02; intercept: p = 0.02). Plasma arginine vasopressin rose more rapidly with increasing plasma osmolality in old subjects.
我们研究了口服水负荷或输注高渗盐水后口渴感、血浆渗透压和精氨酸加压素的同步变化。研究在相同的受试者中进行，包括年龄为26.8岁（标准差4.8，n = 10）的年轻对照组和健康状况明确的72.1岁（标准差3.1，n = 10）的老年人。水负荷导致血浆渗透压（p < 0.001）和口渴感（p < 0.001）显著下降，但不存在年龄差异。输注462 mmol/l的氯化钠显著提高了血浆渗透压（p < 0.001），但不存在年龄差异（p = 0.12）。两个年龄组在渗透负荷实验期间对口渴的感知记录不同（p < 0.0001）。然而，线性回归分析显示，在渗透负荷期间，口渴感与血浆渗透压之间的关系不存在年龄差异。在渗透负荷期间，精氨酸加压素血浆浓度随血浆渗透压升高的关系存在显著差异（斜率：p = 0.02；截距：p = 0.02）。在老年受试者中，精氨酸加压素血浆浓度随血浆渗透压升高的上升速度更快。
