前脑无裂畸形：胼胝体形成及其与大脑半球间裂发育关系的分析
Holoprosencephaly: an analysis of callosal formation and its relation to development of the interhemispheric fissure.
作者信息
Oba H, Barkovich A J
机构信息
Department of Radiology, University of California, San Francisco 94143-0628, USA.
出版信息
AJNR Am J Neuroradiol. 1995 Mar;16(3):453-60.
PURPOSE
To correlate the degree of hemispheric fusion in holoprosencephaly with degree of callosal formation, with degree of thalamic and basal ganglia fusion, and with presence or absence of dorsal cyst.
METHODS
MR, CT, and ultrasonography from 19 patients with holoprosencephaly was retrospectively reviewed. The imaging studies were graded according to extent of the hemispheric fusion, thalamic fusion, corpus striatum fusion, callosal formation, and the presence or absence of a dorsal cyst. These factors were statistically correlated with each other using Kendall rank correlation coefficient.
RESULTS
There were significant correlations between hemispheric fusion and failure of corpus callosum formation, presence of dorsal cyst and failure of corpus callosum formation, and hemispheric fusion and presence of dorsal cyst. Additional correlations were noted between thalamic fusion and corpus striatum fusion.
CONCLUSIONS
Our results suggest that the presence of an interhemispheric fissure is necessary for callosal formation, and the presence of a dorsal cyst may interfere with callosal formation in holoprosencephaly.
目的
将全前脑畸形中半球融合程度与胼胝体形成程度、丘脑和基底神经节融合程度以及背侧囊肿的有无进行关联分析。
方法
回顾性分析19例全前脑畸形患者的磁共振成像（MR）、计算机断层扫描（CT）及超声检查资料。根据半球融合程度、丘脑融合程度、纹状体融合程度、胼胝体形成情况以及背侧囊肿的有无对影像学检查结果进行分级。使用肯德尔等级相关系数对这些因素进行统计学关联分析。
结果
半球融合与胼胝体形成失败、背侧囊肿的存在与胼胝体形成失败以及半球融合与背侧囊肿的存在之间存在显著相关性。此外，还发现丘脑融合与纹状体融合之间存在相关性。
结论
我们的结果表明，半球间裂的存在是胼胝体形成所必需的，背侧囊肿的存在可能会干扰全前脑畸形中的胼胝体形成。
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