Jinkins J R, Whittemore A R, Bradley W G
Huntington Medical Research Institutes, MR Imaging, Pasadena, CA 91105.
AJNR Am J Neuroradiol. 1989 Mar-Apr;10(2):339-44.
Callosal dysgenesis implies a malformation of the corpus callosum with origins in the embryogenesis of the telencephalon. A retrospective review of 15 cases of callosal dysgenesis revealed three distinct categories: agenesis (three subjects), hypogenesis (nine subjects), and hypoplasia (three subjects). The basis of this distinction rests upon considerations of neural tube closure, formation and maintenance of the inductive plate of the massa commissuralis, and migration of the neuronal elements of the cerebral cortex responsible for the projection of the commissural fibers of the corpus callosum. These processes are somewhat interdependent in their expression and consequence, resulting in a unique mosaic of callosal and cortical gray matter and hemispheric white matter configurations that have individually varying clinicoradiologic manifestations.
胼胝体发育不全意味着胼胝体畸形，其起源于端脑的胚胎发育过程。对15例胼胝体发育不全病例的回顾性研究揭示了三种不同类型：发育不全（3例）、发育不良（9例）和发育不全（3例）。这种区分的依据基于对神经管闭合、连合质诱导板的形成和维持，以及负责胼胝体连合纤维投射的大脑皮质神经元成分迁移的考虑。这些过程在其表达和结果上有些相互依存，导致胼胝体和皮质灰质以及半球白质配置形成独特的组合，各自具有不同的临床放射学表现。
