使用冷冻切片术研究阿莫西林在豚鼠体内的胃扩散情况。
Use of cryomicrotomy to study gastric diffusion of amoxicillin in guinea pigs.
作者信息
Lozniewski A, Weber M, De Korwin J D, Conroy M C, Franck P, Floquet J, Le Faou A, Burdin J C
机构信息
Laboratoire de Bactériologie, Centre Hospitalier Universitaire, Nancy, France.
出版信息
Antimicrob Agents Chemother. 1995 Mar;39(3):766-8. doi: 10.1128/AAC.39.3.766.
Abstract
Cryomicrotomy has been used as a new technique for removing gastric mucosae from adult guinea pigs for the study of amoxicillin secretion across gastric mucosae. This method allowed a very regular thickness of the removed surface layer of mucosa to be obtained with good reproducibility. Gastric superficial mucosa concentrations and gastric juice concentrations of amoxicillin were determined 1, 2, and 4 h after intramuscular administration (50 mg/kg) in 21 guinea pigs by a microbiological method. No antibiotic was detected in gastric samples at 4 h, except for a low-level mucosal concentration in one animal, thus indicating the short time that amoxicillin is present in gastric samples.
摘要
冷冻切片术已被用作一种从成年豚鼠身上获取胃黏膜的新技术，用于研究阿莫西林在胃黏膜中的分泌情况。该方法能够获得厚度非常均匀的切除黏膜表层，且具有良好的重复性。通过微生物学方法，在21只豚鼠肌肉注射（50毫克/千克）后1、2和4小时，测定了阿莫西林的胃浅表黏膜浓度和胃液浓度。在4小时时，除一只动物的黏膜浓度较低外，胃样本中未检测到抗生素，这表明阿莫西林在胃样本中的存在时间较短。
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