芽孢瓶霉细胞毒性代谢产物的分离与鉴定
Isolation and characterization of a cytotoxic metabolite of Talaromyces bacillosporus.
作者信息
Ishii K, Itoh T, Kobayashi K, Horie Y, Ueno Y
机构信息
Laboratory of Toxicology and Microbial Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tokyo, Japan.
出版信息
Appl Environ Microbiol. 1995 Mar;61(3):941-3. doi: 10.1128/aem.61.3.941-943.1995.
Abstract
A cytotoxic metabolite, talarotoxin, was isolated from a fungus, Talaromyces bacillosporus IFO 8397, cultured on rice. The structure of the toxin was elucidated and found to contain a pyrrolizidinedione connected with a trans delta 1-octalin through a conjugated triene.
摘要
从在大米上培养的真菌芽孢杆菌青霉IFO 8397中分离出一种细胞毒性代谢物，沙罗毒素。阐明了该毒素的结构，发现其含有一个通过共轭三烯与反式δ1-辛烷连接的吡咯烷二酮。
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