Lake C A, Lake J L, Haebler R, McKinney R, Boothman W S, Sadove S S
Science Applications International Corporation, c/o U.S. Environmental Protection Agency, Narragansett, Rhode Island 02882, USA.
Arch Environ Contam Toxicol. 1995 Jul;29(1):128-34. doi: 10.1007/BF00213097.
The concentrations of polychlorinated biphenyls (PCBs), organochlorine pesticides, polycyclic aromatic hydrocarbons (PAHs), polychlorinated dibenzofurans (PCDF), polychlorinated dibenzo-p-dioxins (PCDD), and mercury (Hg) were determined in blubber and liver tissues of harbor seals (Phoca vitulina) collected along the northeast coast of the U.S. Average PCB concentrations in seal blubber (sum of congeners) were 12.0 micrograms/g (wet weight) with a range of 7.30 to 24.3 micrograms/g in 1980 and 6.66 micrograms/g (wet weight) with a range of 2.61 to 11.3 micrograms/g in 1990-1992. Comparisons between blubber data from this study and previous work indicated that the concentration of PCBs along the northeast coast of the U.S. may have decreased over the past twenty years. The average p,p'-DDE concentrations in seal blubber were 10.9 micrograms/g (wet weight) in 1980 with a range of 6.95 to 21.9 micrograms/g and 4.12 micrograms/g (wet weight) with a range of 1.83 to 7.84 micrograms/g in 1990-1992. Only trace amounts of PCDFs and PCDDs were found in a few blubber samples; levels in most tissues were below detection (3-5 pg/g) (wet weight). Trace amounts (< 30 ng/g) of phenanthracene, anthracene, and alkylated MW-178 compounds were found in some seal samples; all other PAH compounds were below the detection level (5-15 ng/g). Toxic equivalents (TEQ) of selected coplanar and mono-ortho PCB congeners and relative toxic equivalents (RTE) (pg total TEQ/microgram total PCB) were calculated, using recently proposed dioxin toxic equivalent factors (Ahlborg et al. 1994). The TEQs ranged from 41 to 315, and the RTEs ranged from 2.25 to 16.3.(ABSTRACT TRUNCATED AT 250 WORDS)
在美国东北海岸采集的港海豹（Phoca vitulina）的脂肪和肝脏组织中，测定了多氯联苯（PCBs）、有机氯农药、多环芳烃（PAHs）、多氯二苯并呋喃（PCDF）、多氯二苯并对二恶英（PCDD）和汞（Hg）的浓度。1980年，海豹脂肪中多氯联苯的平均浓度（同类物总和）为12.0微克/克（湿重），范围在7.30至24.3微克/克之间；1990 - 1992年为6.66微克/克（湿重），范围在2.61至11.3微克/克之间。本研究的脂肪数据与先前研究的比较表明，过去二十年来，美国东北海岸的多氯联苯浓度可能有所下降。1980年海豹脂肪中p,p'-DDE的平均浓度为10.9微克/克（湿重），范围在6.95至21.9微克/克之间；1990 - 1992年为4.12微克/克（湿重），范围在1.83至7.84微克/克之间。在少数脂肪样本中仅发现痕量的多氯二苯并呋喃和多氯二苯并对二恶英；大多数组织中的含量低于检测限（3 - 5皮克/克）（湿重）。在一些海豹样本中发现痕量（< 30纳克/克）的菲、蒽和烷基化MW - 178化合物；所有其他多环芳烃化合物低于检测限（5 - 15纳克/克）。使用最近提出的二恶英毒性当量因子（Ahlborg等人，1994年）计算了选定的共平面和单邻位多氯联苯同类物的毒性当量（TEQ）和相对毒性当量（RTE）（皮克总TEQ/微克总多氯联苯）。毒性当量范围为41至315，相对毒性当量范围为2.25至16.3。（摘要截断于250字）
