Briffod M
Laboratoire d'Anatomie et Cytologie Pathologiques, Centre René Huguenin, Saint-Cloud.
Arch Anat Cytol Pathol. 1995;43(1-2):19-27.
For the past decade, primary chemotherapy has been extensively used in breast cancer treatment. However, valuable indicators of tumor response are needed. Fine-needle cytopuncture allows the study of malignant cells by cytologic examination, image analysis and flow cytometry. Some parameters evaluated before treatment (cytologic grade, nuclear area and S phase) or at the beginning of treatment (cytomorphologic and cell kinetic changes) have been shown to be correlated with tumor response. The methods, their value and limitations, and results of the literature are discussed.
在过去十年中，原发性化疗已广泛应用于乳腺癌治疗。然而，仍需要有价值的肿瘤反应指标。细针穿刺活检可通过细胞学检查、图像分析和流式细胞术对恶性细胞进行研究。一些在治疗前（细胞学分级、核面积和S期）或治疗开始时（细胞形态学和细胞动力学变化）评估的参数已被证明与肿瘤反应相关。本文将讨论这些方法、其价值和局限性以及文献结果。
