Wing R R, Jeffery R W, Hellerstedt W L
Department of Psychiatry, University of Pittsburg (Pa) School of Medicine, USA.
Arch Intern Med. 1995 Jul 10;155(13):1416-22.
The possible adverse health effects of weight cycling (weight loss followed by weight regain) have been the subject of recent concern. To determine whether such weight cycling negatively influences cardiovascular risk factors, 153 overweight individuals were followed up prospectively through a 30-month weight loss and maintenance program.
Subjects were divided into seven groups according to their weight-change patterns during this 30-month study (steady weight loss of different magnitudes, weight gain, no change in weight, and different weight-cycling patterns). These weight-change groups were compared with regard to lipid levels, blood pressure measurements, waist-to-hip ratio, and percent body fat at 0, 6, 12, 18, and 30 months.
No adverse effects of weight cycling on any of the cardiovascular risk factors were observed. Subjects who initially lost 9.0 kg or more and then regained it did not differ from those who had no change in weight with regard to any cardiovascular risk factor at month 30. Subjects who gained weight during the 30-month interval increased their risk factors, those who lost weight decreased their risk factors in proportion to the magnitude of weight loss, and, in general, cardiovascular risk factors at month 30 were related to the net weight loss achieved and not the route taken to achieve the weight loss.
This study showed no negative effects of weight cycling on cardiovascular risk factors and confirmed previous findings of positive effects of weight loss on risk factors. Therefore, overweight individuals should be encouraged to lose weight and then maintain their weight loss.
体重循环（体重下降后又恢复）可能对健康产生的不良影响是近期人们关注的话题。为了确定这种体重循环是否会对心血管危险因素产生负面影响，153名超重个体通过一个为期30个月的体重减轻及维持计划进行了前瞻性随访。
在这项为期30个月的研究中，根据受试者的体重变化模式将他们分为七组（不同幅度的稳定体重减轻、体重增加、体重无变化以及不同的体重循环模式）。在第0、6、12、18和30个月时，对这些体重变化组在血脂水平、血压测量、腰臀比和体脂百分比方面进行比较。
未观察到体重循环对任何心血管危险因素有不良影响。在第30个月时，最初体重减轻9.0千克或更多然后又恢复体重的受试者与体重无变化的受试者在任何心血管危险因素方面均无差异。在30个月期间体重增加的受试者其危险因素增加，体重减轻的受试者其危险因素按体重减轻幅度相应降低，总体而言，第30个月时的心血管危险因素与实现的净体重减轻有关，而与实现体重减轻所采取的途径无关。
本研究表明体重循环对心血管危险因素没有负面影响，并证实了先前关于体重减轻对危险因素有积极影响的研究结果。因此，应鼓励超重个体减肥并维持体重减轻。
