Shi J, Dai G, Zhang Z
Department of Epidemiology, China Medical University, Shenyang.
Zhonghua Yu Fang Yi Xue Za Zhi. 1995 Mar;29(2):103-5.
Relationship between bone fluoride content, pathological change in bone of aborted fetuses and maternal fluoride level was studied in 46 pregnant women and their inducedly-aborted fetuses. Results showed fluoride content in fetal femur averaged 368.2 micrograms/g, and 41.4% of the bone with pathological change. Fluoride levels in maternal urine and amniotic fluid and fluoride content in fetal femur and pathological change in fetal femur appeared a positive correlation between them. Femur fluoride content and pathological change of bone in fetuses born to mothers with mottling teeth were significantly greater than to those without them. Pathological change in fetal femur presented dose-response relationship with their bone fluoride content. When the latter reached greater than 500 micrograms/g, pathological changes occurred in 90% of the bone.
对46名孕妇及其人工流产胎儿的骨氟含量、胎儿骨骼病理变化与母体氟水平之间的关系进行了研究。结果显示，胎儿股骨中的氟含量平均为368.2微克/克，41.4%的骨骼有病理变化。母体尿液和羊水中的氟水平与胎儿股骨中的氟含量以及胎儿股骨的病理变化之间呈正相关。有氟斑牙的母亲所生胎儿的股骨氟含量和骨骼病理变化明显高于无氟斑牙的母亲所生胎儿。胎儿股骨的病理变化与其骨氟含量呈剂量反应关系。当后者超过500微克/克时，90%的骨骼出现病理变化。
