Eberhart C E, Dubois R N
Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Gastroenterology. 1995 Jul;109(1):285-301. doi: 10.1016/0016-5085(95)90296-1.
Determining the role of eicosanoids in gastrointestinal physiology and pathophysiology has been an active area of investigation over the past 20 years. The landmark discovery of prostaglandin endoperoxide synthase and other enzymes involved in the production of arachidonic acid products (lipoxygenases and epoxygenases) ushered in a new era of research. The goal of this review is to distill a large body of work pertaining to studies of eicosanoids in the gastrointestinal tract. This review has been organized according both to functional (secretion and motility) and disease-related (inflammation, mucosal injury, and neoplasia) effects. The aim of this article is to present a clear summary of this area of gastroenterology so that future research can be directed in a logical and productive manner.
在过去20年里，确定类花生酸在胃肠道生理和病理生理中的作用一直是一个活跃的研究领域。前列腺素内过氧化物合酶以及其他参与花生四烯酸产物生成的酶（脂氧合酶和环氧化酶）的里程碑式发现开启了一个新的研究时代。本综述的目的是提炼出大量与胃肠道类花生酸研究相关的工作。本综述根据功能（分泌和运动）以及与疾病相关的（炎症、粘膜损伤和肿瘤形成）效应进行了组织。本文的目的是对胃肠病学这一领域进行清晰的总结，以便未来的研究能够以合乎逻辑且富有成效的方式进行。
