胆囊切除术前术后胆结石患者幽门螺杆菌的患病率：一项纵向研究
Prevalence of Helicobacter pylori in patients with gall stones before and after cholecystectomy: a longitudinal study.
作者信息
Farsakh N A, Roweily E, Steitieh M, Butchoun R, Khalil B
机构信息
Department of Internal Medicine, Jordan University of Science and Technology, Irbid.
出版信息
Gut. 1995 May;36(5):675-8. doi: 10.1136/gut.36.5.675.
Fifty six patients with gall stones were enrolled in this study to assess the presence of Helicobacter pylori in gastric mucosa before and after cholecystectomy. Samples were taken from gastric juice and antral mucosa through endoscopy performed on these patients before and after the operation. Gastric juice was examined for bile salt concentration as an indicator of duodenogastric reflux. Antral mucosa was studied for the presence of H pylori and inflammatory response. Duodenogastric reflux was significantly increased (p < 0.001) and H pylori significantly decreased (p < 0.01) in the postoperative period. Mucosal inflammation and its activity were less in the postoperative period but the differences did not reach statistically significant values.
本研究纳入了56例胆结石患者，以评估胆囊切除术前、后胃黏膜中幽门螺杆菌的存在情况。通过对这些患者在手术前、后进行内镜检查，从胃液和胃窦黏膜采集样本。检测胃液中的胆汁盐浓度，作为十二指肠-胃反流的指标。研究胃窦黏膜中幽门螺杆菌的存在情况及炎症反应。术后十二指肠-胃反流显著增加（p<0.001），幽门螺杆菌显著减少（p<0.01）。术后黏膜炎症及其活动程度较轻，但差异未达到统计学显著水平。
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