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后巩膜炎的免疫病理学发现。

Immunopathological findings in posterior scleritis.

作者信息

Bernauer W, Büchi E R, Daicker B

机构信息

University Eye Hospital, Basel, Switzerland.

出版信息

Int Ophthalmol. 1994;18(4):229-31. doi: 10.1007/BF00951803.

DOI:10.1007/BF00951803
PMID:7797388
Abstract

Posterior scleritis can present with a variety of symptoms, and its clinical diagnosis is therefore difficult. Little is known about the pathogenesis and the cellular effector mechanisms. This case report presents the immunopathological findings of posterior scleritis in the enucleated eye of a 28-year-old female with no known underlying disease. The cells infiltrating the scleral fibers consisted predominantly of T cells. Many of them were CD4 cells. Clusters of T and B cells were found in perivascular areas. No signs of primary vasculitis were seen. The cellular infiltrate in posterior scleritis shows features compatible with a T-cell-mediated (autoimmune) disorder.

摘要

后巩膜炎可表现出多种症状,因此其临床诊断较为困难。目前对其发病机制和细胞效应机制了解甚少。本病例报告展示了一名无已知基础疾病的28岁女性摘除眼球中后巩膜炎的免疫病理学发现。浸润巩膜纤维的细胞主要由T细胞组成。其中许多是CD4细胞。在血管周围区域发现了T细胞和B细胞簇。未发现原发性血管炎的迹象。后巩膜炎中的细胞浸润表现出与T细胞介导的(自身免疫性)疾病相符的特征。

相似文献

1
Immunopathological findings in posterior scleritis.后巩膜炎的免疫病理学发现。
Int Ophthalmol. 1994;18(4):229-31. doi: 10.1007/BF00951803.
2
[Inflammatory cellular infiltration in scleritis].[巩膜炎中的炎性细胞浸润]
Ophthalmologe. 1995 Feb;92(1):46-8.
3
Cells perpetuating the inflammatory response in scleritis.巩膜炎中持续炎症反应的细胞。
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4
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IgG4-related disease involving the sclera.累及巩膜的 IgG4 相关疾病。
Mod Rheumatol. 2014 Jan;24(1):195-8. doi: 10.3109/14397595.2013.852842.
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Necrotizing scleritis after ocular surgery. A clinicopathologic study.
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Infectious posterior scleritis caused by Pseudallescheria boydii. Clinicopathologic findings.波氏假阿利什菌引起的感染性后巩膜炎。临床病理发现。
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Scleritis: Immunopathogenesis and molecular basis for therapy.巩膜炎:发病机制与治疗的分子基础。
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Turk J Ophthalmol. 2017 Dec;47(6):315-319. doi: 10.4274/tjo.58712. Epub 2017 Dec 25.
3
Scleritis and peripheral ulcerative keratitis.巩膜炎和周边溃疡性角膜炎。

本文引用的文献

1
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Posterior scleritis.后巩膜炎
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Br J Ophthalmol. 1991 Jun;75(6):340-1. doi: 10.1136/bjo.75.6.340.
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Necrotizing scleritis after ocular surgery. A clinicopathologic study.
Ophthalmology. 1991 Nov;98(11):1720-6. doi: 10.1016/s0161-6420(91)32062-1.
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Immunopathology of scleritis.
Ophthalmology. 1991 Apr;98(4):472-9. doi: 10.1016/s0161-6420(91)32280-2.
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Cyclosporine A for the treatment of necrotizing scleritis and corneal melting in patients with rheumatoid arthritis.环孢素A用于治疗类风湿关节炎患者的坏死性巩膜炎和角膜溶解。
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