Wakefield D, McCluskey P
School of Pathology, University of New South Wales, Kensington, Australia.
Br J Ophthalmol. 1989 Sep;73(9):743-6. doi: 10.1136/bjo.73.9.743.
To ascertain the efficacy of systemic cyclosporin therapy in the management of scleritis we performed an open, uncontrolled study of the use of this drug in severe refractory disease. Five of seven patients whose disease had previously been poorly controlled with a combination of corticosteroids and immunosuppressive drugs responded to cyclosporin therapy (10 mg/kg/day). Systemic side effects occurred in all but one patient, with tremor, hirsutism, hypertension, and raised serum creatinine being common. Recurrence of disease activity on decreasing the dosage of cyclosporin was frequent. The results indicate that cyclosporin is a useful additional drug in the treatment of severe scleritis.
为确定全身应用环孢素治疗巩膜炎的疗效，我们对该药在严重难治性疾病中的应用进行了一项开放性、非对照研究。7例先前使用皮质类固醇和免疫抑制药物联合治疗效果不佳的患者中，有5例对环孢素治疗（10mg/kg/天）有反应。除1例患者外，所有患者均出现全身副作用，常见的有震颤、多毛症、高血压和血清肌酐升高。降低环孢素剂量时疾病活动复发很常见。结果表明，环孢素是治疗严重巩膜炎的一种有用的辅助药物。
