Yamamoto T, Furuse Y, Katayama I, Nishioka K
Department of Dermatology, Tokyo Medical and Dental University School of Medicine, Japan.
J Dermatol. 1994 Oct;21(10):751-4. doi: 10.1111/j.1346-8138.1994.tb03282.x.
A patient with progressive systemic sclerosis and high levels of serum IgE developed multiple papules at/on an area of non-sclerotic skin. Histologic examination of the papule revealed the typical features of scleroderma. For several years, the patient had been working on polishing watches with an abrasive agent composed mainly of aluminum, chromium dioxide, and silica. An association of the abrasive agent, especially of the silica component, with the scleroderma was circumstantially suspected. To the best of our knowledge, this is the first report of nodular scleroderma which occurred in the course of PSS being associated with chemical agents.
一名患有进行性系统性硬化症且血清IgE水平较高的患者，在非硬化皮肤区域出现了多个丘疹。对丘疹进行组织学检查发现了硬皮病的典型特征。数年来，该患者一直使用一种主要由铝、二氧化铬和二氧化硅组成的研磨剂从事手表抛光工作。由此推测这种研磨剂，尤其是其中的二氧化硅成分，与硬皮病之间可能存在关联。据我们所知，这是首例报道的在进行性系统性硬化症病程中出现的结节性硬皮病与化学制剂相关的病例。
