7至17岁儿童随机样本中血清总IgE的预测因素
Predictors of Serum Total IgE in a Random Sample of 7-17 Year Old Children.
作者信息
Strømgaard Sofie, Thomsen Simon Francis, Fenger Mogens, Backer Vibeke
机构信息
Department of Respiratory Medicine, Bispebjerg Hospital, 2400 Copenhagen, Denmark.
出版信息
ISRN Allergy. 2011 May 31;2011:169859. doi: 10.5402/2011/169859. Print 2011.
Background. There is little knowledge of the causes for raised serum total immunoglobulin E (IgE) in children. We investigated the association between perinatal, socioeconomic, demographic, clinical, paraclinical, and early life factors, and total serum IgE. Methods. In a random sample of 7-17 year old children, data on possible risk factors were collected using a questionnaire and total serum IgE was measured in venous blood. Airway responsiveness to inhaled histamine was measured and skin prick tests were performed using common aeroallergens. Data was analysed using linear regression. Results. Positive skin prick test (P < .001), airway hyperresponsiveness (P = .003), atopic dermatitis (P = .046), and parental predisposition to allergy (P = .047) showed a significant relation to serum total IgE levels. There was no association of smoking to serum total IgE. Conclusions. This study showed a strong positive relationship between markers of the atopic syndrome and serum total IgE levels in children. In contrast to some earlier studies, we did not find a significant relation between smoking status and IgE.
背景。对于儿童血清总免疫球蛋白E（IgE）升高的原因了解甚少。我们调查了围产期、社会经济、人口统计学、临床、辅助检查及早期生活因素与血清总IgE之间的关联。方法。在一个7至17岁儿童的随机样本中，通过问卷调查收集可能的危险因素数据，并检测静脉血中的血清总IgE。测量气道对吸入组胺的反应性，并使用常见的空气过敏原进行皮肤点刺试验。采用线性回归分析数据。结果。皮肤点刺试验阳性（P < 0.001）、气道高反应性（P = 0.003）、特应性皮炎（P = 0.046）以及父母的过敏易感性（P = 0.047）与血清总IgE水平显著相关。吸烟与血清总IgE无关联。结论。本研究表明儿童特应性综合征标志物与血清总IgE水平之间存在强正相关。与一些早期研究不同，我们未发现吸烟状况与IgE之间存在显著关联。
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