Niggemann B, Beyer K, Wahn U
Division of Pediatric Pneumology and Immunology, University Children's Hospital (KAVH), Berlin, Germany.
J Allergy Clin Immunol. 1994 Dec;94(6 Pt 1):963-71. doi: 10.1016/0091-6749(94)90114-7.
To investigate the role of peripheral blood eosinophils and eosinophil cationic protein as parameters in monitoring oral food challenges, we monitored 25 infants and children with atopic dermatitis for up to 48 hours after 47 placebo-controlled oral food challenges with cow's milk, hen's egg, cow's milk and hen's egg, or placebo for up to 48 hours. Six healthy young nonatopic adult volunteers served as control subjects. Compared with baseline values, peripheral blood eosinophils decreased significantly immediately after clinical reaction in positive challenges (p < 0.0004), independent of the kind of reaction. Eosinophil cationic protein increased significantly 8 hours after provocation, with a maximum at 24 hours (p < 0.03). This increase was predominantly related to eczematous reactions (p < 0.005). Blood sampling immediately after clinical reaction (for eosinophils) and at 24 hours (for eosinophil cationic protein) seems to be useful in monitoring oral food challenges in children with atopic dermatitis.
为了研究外周血嗜酸性粒细胞和嗜酸性粒细胞阳离子蛋白作为监测口服食物激发试验参数的作用，我们对25名患有特应性皮炎的婴幼儿进行了监测，在47次用牛奶、鸡蛋、牛奶和鸡蛋或安慰剂进行的安慰剂对照口服食物激发试验后长达48小时。6名健康的非特应性年轻成年志愿者作为对照。与基线值相比，阳性激发试验中临床反应后外周血嗜酸性粒细胞立即显著下降（p<0.0004），与反应类型无关。激发后8小时嗜酸性粒细胞阳离子蛋白显著增加，在24小时达到峰值（p<0.03）。这种增加主要与湿疹反应有关（p<0.005）。临床反应后立即（用于检测嗜酸性粒细胞）和24小时（用于检测嗜酸性粒细胞阳离子蛋白）采血似乎有助于监测特应性皮炎患儿的口服食物激发试验。
