Kapp A, Czech W, Krutmann J, Schöpf E
Department of Dermatology, University of Freiburg, F.R.G.
J Am Acad Dermatol. 1991 Apr;24(4):555-8. doi: 10.1016/0190-9622(91)70081-c.
Patients with atopic dermatitis frequently show elevated blood eosinophil counts, and eosinophil-derived major basic protein has been demonstrated in the eczematous skin from patients with atopic dermatitis. To evaluate further the role of eosinophils in the pathogenesis of atopic dermatitis, the concentration of eosinophil cationic protein was measured in serum samples of 42 patients with moderate to severe disease. The results were compared with those obtained in 32 patients with psoriasis with (n = 9) or without (n = 23) a history of inhalant allergy, 12 patients with a history of pseudoallergic reactions to acetylsalicylic acid, 14 patients with a history of inhalant allergy, and 31 nonatopic healthy control subjects. Eosinophil cationic protein levels were significantly increased in the serum of patients with atopic dermatitis (p less than or equal to 0.005) and patients with a history of pseudoallergic reactions to acetylsalicylic acid (p less than or equal to 0.01). There was no significant difference between eosinophil cationic protein levels in patients with psoriasis or a history of inhalant allergy and in control subjects. Moreover, eosinophil cationic protein levels did not differ significantly in psoriasis patients with or without inhalant allergy. These studies support the concept of an active participation of eosinophils in atopic dermatitis and point to a possible role for eosinophils in pseudoallergy.
特应性皮炎患者常表现出血液嗜酸性粒细胞计数升高，并且在特应性皮炎患者的湿疹皮肤中已证实存在嗜酸性粒细胞衍生的主要碱性蛋白。为了进一步评估嗜酸性粒细胞在特应性皮炎发病机制中的作用，对42例中重度疾病患者的血清样本中嗜酸性粒细胞阳离子蛋白的浓度进行了测量。将结果与32例有（n = 9）或无（n = 23）吸入性过敏史的银屑病患者、12例有对乙酰水杨酸假过敏反应史的患者、14例有吸入性过敏史的患者以及31名非特应性健康对照者的结果进行了比较。特应性皮炎患者血清中的嗜酸性粒细胞阳离子蛋白水平显著升高（p≤0.005），有对乙酰水杨酸假过敏反应史的患者血清中的嗜酸性粒细胞阳离子蛋白水平也显著升高（p≤0.01）。银屑病患者或有吸入性过敏史的患者与对照者之间的嗜酸性粒细胞阳离子蛋白水平无显著差异。此外，有或无吸入性过敏的银屑病患者的嗜酸性粒细胞阳离子蛋白水平也无显著差异。这些研究支持嗜酸性粒细胞积极参与特应性皮炎发病机制的概念，并指出嗜酸性粒细胞在假过敏中可能发挥的作用。
