Casapullo A, Minale L, Zollo F
Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli "Federico II," Italy.
J Nat Prod. 1994 Sep;57(9):1227-33. doi: 10.1021/np50111a006.
Following the characterization of anchinopeptolide A[1], three new congeneric dimeric peptide alkaloids, named anchinopeptolides B [2], C[3], and D[4], have been isolated from the Mediterranean sponge Anchinoe tenacior. A fourth compound, cycloanchinopeptolide C[5], which is related to anchinopeptolide C[3] by a head-to-head intramolecular [2+2] cyclo-addition reaction, has also been isolated. The structures of these peptide alkaloids have been elucidated on the basis of spectral evidence. Anchinopeptolides bind to the somatostatin, human B2 bradykinin, and neuropeptide Y receptors.
在对安奇诺肽A[1]进行表征之后，从地中海海绵Anchinoe tenacior中分离出了三种新的同属二聚体肽生物碱，分别命名为安奇诺肽B[2]、C[3]和D[4]。还分离出了第四种化合物环安奇诺肽C[5]，它通过头对头分子内[2+2]环加成反应与安奇诺肽C[3]相关。这些肽生物碱的结构已根据光谱证据得以阐明。安奇诺肽与生长抑素、人B2缓激肽和神经肽Y受体结合。
