Bifulco G, Bruno I, Riccio R, Lavayre J, Bourdy G
Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli Ferderico II, Italy.
J Nat Prod. 1995 Aug;58(8):1254-60. doi: 10.1021/np50122a017.
Two tris-indole alkaloids, (+/-) gelliusines A and B [1], have been isolated for the first time from a marine source, the New Caledonian sponge, Orina sp. (or Gellius sp.), along with five further indole constituents [2-6]. Compound 6 has been identified as 2,2-bis-(6'-bromo-3'-indolyl(-ethylamine, previously isolated from the tunicate Didemnum candidum, but the remaining four indoles [2-5] are novel compounds. These showed anti-serotonin activity and a strong affinity for somatostatin and neuropeptide Y receptors in receptor-binding assays.
首次从海洋来源新喀里多尼亚海绵Orina sp.（或Gellius sp.）中分离出两种三吲哚生物碱，即（±）盖利辛A和B [1]，同时，同时还分离出另外五种吲哚成分[2-6]。化合物6已被鉴定为2,2-双-（6'-溴-3'-吲哚基）乙胺，该化合物先前已从被囊动物白色皮海鞘中分离得到，但其余四种吲哚[2-5]是新化合物。在受体结合试验中，这些化合物表现出抗血清素活性，并对生长抑素和神经肽Y受体具有很强的亲和力。
