抑郁症患者基底节中三磷酸核苷水平较低：一项磷-31磁共振波谱研究。
Lower levels of nucleoside triphosphate in the basal ganglia of depressed subjects: a phosphorous-31 magnetic resonance spectroscopy study.
作者信息
Moore C M, Christensen J D, Lafer B, Fava M, Renshaw P F
机构信息
Brain Imaging Center, McLean Hospital, Belmont, MA 02178, USA.
出版信息
Am J Psychiatry. 1997 Jan;154(1):116-8. doi: 10.1176/ajp.154.1.116.
OBJECTIVE
The purpose of this study was to evaluate whether the concentration of beta-nucleoside triphosphate is lower in the basal ganglia of depressed subjects.
METHOD
In vivo 31P magnetic resonance spectra were acquired from a 45-cm3 region surrounding the basal ganglia of 35 unmedicated depressed subjects and 18 comparison subjects.
RESULTS
beta-Nucleoside triphosphate, which arises primarily from beta-ATP, was 16% lower in the depressed subjects than in the comparison subjects.
CONCLUSIONS
The low level of beta-nucleoside triphosphate is consistent with an abnormality of high-energy phosphate metabolism in the basal ganglia of subjects with major depression.
目的
本研究旨在评估抑郁症患者基底节中β-核苷三磷酸的浓度是否较低。
方法
对35名未接受药物治疗的抑郁症患者和18名对照受试者，在其基底节周围45立方厘米的区域采集体内31P磁共振波谱。
结果
主要由β-ATP产生的β-核苷三磷酸，在抑郁症患者中比对照受试者低16%。
结论
β-核苷三磷酸水平低与重度抑郁症患者基底节高能磷酸代谢异常一致。
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