Jacobi P C, Walter P, Brunner R, Krieglstein G K
Department of Ophthalmology, University of Cologne, Germany.
Ger J Ophthalmol. 1994 Aug;3(4-5):216-9.
The human pattern electroretinogram (PERG) is a contrast-specific potential presumedly reflecting the functional integrity of ganglion cells. Many studies have devised criteria that enable PERG measurements to distinguish established glaucomatous (hypertonic) eyes from normal controls. As there are relatively few reports concerning the reproducibility and reliability of the PERG, we studied the intraindividual variability of the PERG in 20 healthy subjects. Both transient and steady-state responses were recorded using a high-contrast (98%), black-and-white, counterphasing checkerboard pattern (average luminance, 80 cd/m2) generated by a television monitor (subtending angle, 13.8 degrees x 10.8 degrees) using three different check sizes (15', 30', and 60'). Recordings were performed in both eyes simultaneously at a 7-day interval under test-retest conditions. Responses of 30' spatial frequency were most consistent and resulted in a mean amplitude (+/- SD) of 2.18 +/- 0.95 microV (P50) and 4.00 +/- 1.69 microV (N95) for transient patterns and 1.84 +/- 1.25 microV for steady-state patterns. No statistically significant difference was observed between either right and left eyes, test and retest conditions or 1st- and 7th-day recording sessions for PERG parameters. In linear correlation analysis there was an adequate, positive correlation between the right and left eyes (r = 0.78); a weak correlation between test and retest conditions (r = 0.58); and no correlation between measurements made at a 7-day interval. As a consequence, we conclude that the follow-up of patients (e.g., glaucoma, ocular hypertension) by means of PERG is critical, especially when therapeutic consequences may be based on the physiological variability of a weak retinal signal.(ABSTRACT TRUNCATED AT 250 WORDS)
人类图形视网膜电图（PERG）是一种对比度特异性电位，推测反映了神经节细胞的功能完整性。许多研究已经制定了标准，使PERG测量能够区分已确诊的青光眼（高眼压）眼和正常对照。由于关于PERG的可重复性和可靠性的报告相对较少，我们研究了20名健康受试者PERG的个体内变异性。使用电视监视器（视角为13.8度×10.8度）产生的高对比度（98%）、黑白、反相棋盘格图案（平均亮度，80 cd/m²），采用三种不同的方格大小（15'、30'和60'）记录瞬态和稳态反应。在重测条件下，两眼同时以7天的间隔进行记录。30'空间频率的反应最一致，瞬态图案的平均振幅（±标准差）为2.18±0.95 μV（P50）和4.00±1.69 μV（N95），稳态图案为1.84±1.25 μV。PERG参数在左右眼、测试和重测条件或第1天和第7天记录时段之间均未观察到统计学上的显著差异。在线性相关分析中，左右眼之间存在充分的正相关（r = 0.78）；测试和重测条件之间存在弱相关（r = 0.58）；7天间隔测量之间无相关性。因此，我们得出结论，通过PERG对患者（如青光眼、高眼压症）进行随访至关重要，尤其是当治疗结果可能基于微弱视网膜信号的生理变异性时。（摘要截断于250字）
