Davis C E, Pajak A, Rywik S, Williams D H, Broda G, Pazucha T, Ephross S
School of Public Health, Department of Biostatistics, University of North Carolina, Chapel Hill.
Ann Epidemiol. 1994 Nov;4(6):445-8. doi: 10.1016/1047-2797(94)90003-5.
Changes in risk factor levels associated with menopause have been reported in many studies in the United States and western Europe, where estrogen replacement therapy and surgical menopause are common. We studied risk factor associations in Polish women, for whom estrogen replacement therapy and surgical menopause are uncommon. The 357 postmenopausal women had higher total cholesterol levels (0.43 mmol/L) and low-density-lipoprotein cholesterol levels (0.36 mmol/L than did the 372 premenopausal women of similar ages. Triglycerides, high-density-lipoprotein cholesterol, body mass index, and blood pressure did not differ by menopausal status. We conclude that natural menopause is associated with higher levels of total and low-density-lipoprotein cholesterol levels. Natural menopause is not associated with large changes in other risk factors in this sample.
在美国和西欧的许多研究中，都报告了与绝经相关的风险因素水平变化，在这些地区，雌激素替代疗法和手术绝经很常见。我们研究了波兰女性的风险因素关联，对她们来说，雌激素替代疗法和手术绝经并不常见。357名绝经后女性的总胆固醇水平（0.43毫摩尔/升）和低密度脂蛋白胆固醇水平（比372名年龄相仿的绝经前女性高0.36毫摩尔/升）更高。甘油三酯、高密度脂蛋白胆固醇、体重指数和血压在绝经状态上没有差异。我们得出结论，自然绝经与总胆固醇和低密度脂蛋白胆固醇水平升高有关。在这个样本中，自然绝经与其他风险因素的大幅变化无关。
