女性生殖道尖锐湿疣及其他良性病变中的人乳头瘤病毒
Human papillomavirus in condyloma acuminata and other benign lesions of the female genital tract.
作者信息
Cui M H, Liu Y Q, Li H L, Li S R
机构信息
Department of Obstetrics and Gynecology, Second Teaching Hospital, N Bethune University of Medical Sciences, Changchun.
出版信息
Chin Med J (Engl). 1994 Sep;107(9):703-8.
PCR was used to detect (HPV) in condyloma acuminata (CA), pseudocondyloma whose cause is unclear, and the other benign lesions in female genital tract. The results showed that HPV prevalence rate in CA was 98.2%, type 6 was in 11 was 85.7%, and that in pseudocondyloma, cervical polyp, cervical erosion and chronic vaginitis was 40.4%, 76.2%, 77.3% and 16.0%, respectively. Even in normal vaginal tissue, there existed HPV subclinical infection. HPV prevalence rate in swabs from patient's underwears and normal vaginal tissues was 73.6% and 54.0% respectively. The investigation of estrogen receptor (ER) in CA tissue carried out by immunohistochemical method found that positive ER was achieved in most of CA, and few of normal vulvar tissues was found. This result indicated that the occurrence of CA is probably related to estrogen.
采用聚合酶链反应（PCR）检测尖锐湿疣（CA）、病因不明的假性湿疣及女性生殖道其他良性病变中的人乳头瘤病毒（HPV）。结果显示，CA中HPV感染率为98.2%，其中11例6型占85.7%；假性湿疣、宫颈息肉、宫颈糜烂和慢性阴道炎中HPV感染率分别为40.4%、76.2%、77.3%和16.0%。即使在正常阴道组织中，也存在HPV亚临床感染。患者内裤拭子及正常阴道组织中HPV感染率分别为73.6%和54.0%。采用免疫组织化学方法对CA组织进行雌激素受体（ER）检测，发现多数CA组织ER呈阳性，而正常外阴组织中少见。该结果提示CA的发生可能与雌激素有关。
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