Liu H G, Niu R J, Hu D Z
Tongji Hospital, Tongji Medical University.
Zhonghua Nei Ke Za Zhi. 1994 Mar;33(3):150-3.
The number of glucocorticoid receptors (GCR) in peripheral leukocytes was determined by radioligand-binding assay in extrinsic and intrinsic asthmatics. Their corresponding plasma cortisol levels were assessed. The results showed that the average number of GCR in asthmatics was significantly lower than that in healthy subjects (P < 0.01), and there was a linear correlation between the number of GCR and the course of asthma. Besides, there was also a linear correlation between the number of GCR and the age of the initial attack of asthma. No difference in plasma cortisol level was found between asthmatics and healthy subjects. These findings suggest that there is no primary and general impairment of glucocorticoid metabolism in the asthmatics, but the number of GCR in the asthmatics is lower than that in healthy controls. The decrease of the number of GCR in asthmatics, we think, is related to heredity and repeated attacks of asthma.
采用放射性配体结合分析法测定了外源性和内源性哮喘患者外周血白细胞中糖皮质激素受体（GCR）的数量，并评估了他们相应的血浆皮质醇水平。结果显示，哮喘患者GCR的平均数量显著低于健康受试者（P < 0.01），且GCR数量与哮喘病程之间存在线性相关性。此外，GCR数量与哮喘初发年龄之间也存在线性相关性。哮喘患者与健康受试者的血浆皮质醇水平未发现差异。这些发现表明，哮喘患者不存在糖皮质激素代谢的原发性和全身性损害，但哮喘患者的GCR数量低于健康对照。我们认为，哮喘患者GCR数量的减少与遗传及哮喘的反复发作有关。
