Pucci G, Martino M, Morabito F, Iacopino P, Arcese W, Iori A P, Lombardo V T, L'Abbate A, Santostefano M, Nobile F
Department of Hematology, OORR, Reggio Calabria, Italy.
Haematologica. 1994 Jul-Aug;79(4):371-3.
Thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS) usually occurs in a setting of systemic infection or graft-versus-host reaction during the first weeks following transplant. We report a case of fatal TTP that developed eight months after allogeneic bone marrow transplantation (BMT) without any evident association with other transplantation-related complications. Conditioning chemotherapy could have induced the disorder by causing damage to the vascular endothelium. The removal of immunosuppression, including cessation of cyclosporin A (CyA), may have precipitated the disease.
