Riesgo-Escovar J R, Woodard C, Carlson J R
Department of Biology, Yale University, New Haven, CT 06511-8112.
J Comp Physiol A. 1994 Dec;175(6):687-93. doi: 10.1007/BF00191841.
We describe the kinetics of odorant response in the maxillary palp of Drosophila, and show that the rate of recovery from odorant stimulation is affected by mutation of the rdgB (retinal degeneration B) gene. We use immunocytochemistry to confirm that the rdgB gene product is expressed in the maxillary palp. rdgB has recently been shown to encode a protein with Ca(2+)-binding sites and sequence similarity to rat brain phosphatidylinositol transfer protein; it is located near the rhabdomeric membranes in photoreceptor cells, where it has been suggested to play a role in membrane transport. The delay in recovery kinetics that we observe in olfactory tissue may reflect a defect in membrane restoration at the conclusion of the olfactory transduction cascade. The use of common molecules in the physiology of two olfactory organs, and in both visual and olfactory physiology, is discussed.
我们描述了果蝇上颌触须中气味反应的动力学，并表明从气味刺激中恢复的速率受rdgB（视网膜变性B）基因突变的影响。我们使用免疫细胞化学来证实rdgB基因产物在上颌触须中表达。最近发现rdgB编码一种具有钙结合位点且与大鼠脑磷脂酰肌醇转移蛋白序列相似的蛋白质；它位于光感受器细胞的微绒毛膜附近，有人认为它在膜运输中起作用。我们在嗅觉组织中观察到的恢复动力学延迟可能反映了嗅觉转导级联结束时膜修复的缺陷。本文还讨论了两个嗅觉器官的生理学以及视觉和嗅觉生理学中共同分子的使用情况。
