Holmquist G P
Department of Biology, Beckman Research Institute, City of Hope Medical Center, Duarte, CA 91010.
J Mol Evol. 1994 Nov;39(5):436-8. doi: 10.1007/BF00173411.
Proteins, on binding to a DNA sequence, alter the frequency and quality of mutations that occur in the sequence. This represents a reverse flow of information from proteins to DNA. Nucleosome binding causes patterns of UV-induced damage which, when converted to mutations by replication, will phase nucleosomes. We propose that DNA binding proteins create their own high- or low-affinity binding sites along DNA sequences by biased mutational pressure.
蛋白质与DNA序列结合后，会改变该序列中发生突变的频率和性质。这代表了从蛋白质到DNA的反向信息流。核小体结合会导致紫外线诱导的损伤模式，这种损伤在复制过程中转化为突变时，会使核小体定相。我们提出，DNA结合蛋白通过有偏向性的突变压力沿着DNA序列创建自身的高亲和力或低亲和力结合位点。
