Ware J C, Rose F V, McBrayer R H
Department of Medicine, Eastern Virginia Medical School, Norfolk.
Sleep. 1994 Sep;17(6):544-50. doi: 10.1093/sleep/17.6.544.
This study examined the effects of nefazodone, trazodone and buspirone on sleep and sleep-related penile tumescence. Trazodone is a sedating antidepressant without anticholinergic properties. Nefazodone is a new antidepressant that is a structural analogue of trazodone but is less sedating. Buspirone is a nonsedating, nonbenzodiazepine anxiolytic with antidepressant properties. Nefazodone was compared to trazodone and buspirone in a double-blind, placebo-controlled crossover study in 12 normal healthy males. Nefazodone increased rapid eye movement (REM) sleep, whereas trazodone and buspirone suppressed REM sleep. The drugs only minimally affected other sleep stages. Trazodone increased total tumescence time by delaying the onset of detumescence; nefazodone increased total tumescence time only insofar as it increased REM sleep; buspirone did not change total tumescence time when compared to placebo. The results support a growing body of data indicating that not all antidepressants suppress REM sleep. The results also are consistent with the interpretation of an earlier study showing that trazodone prolongs penile tumescence during sleep as a result of its alpha-adrenergic blocking properties that suppress detumescence. Nefazodone, with less alpha-adrenergic blocking activity, did not abnormally penile tumescence beyond REM sleep.
本研究考察了奈法唑酮、曲唑酮和丁螺环酮对睡眠及与睡眠相关的阴茎勃起的影响。曲唑酮是一种无抗胆碱能特性的镇静性抗抑郁药。奈法唑酮是一种新型抗抑郁药，是曲唑酮的结构类似物，但镇静作用较弱。丁螺环酮是一种无镇静作用的非苯二氮䓬类抗焦虑药，具有抗抑郁特性。在一项针对12名正常健康男性的双盲、安慰剂对照交叉研究中，对奈法唑酮与曲唑酮和丁螺环酮进行了比较。奈法唑酮增加快速眼动（REM）睡眠，而曲唑酮和丁螺环酮则抑制REM睡眠。这些药物对其他睡眠阶段的影响极小。曲唑酮通过延迟疲软的开始来增加总勃起时间；奈法唑酮仅在增加REM睡眠的程度上增加总勃起时间；与安慰剂相比，丁螺环酮不改变总勃起时间。这些结果支持了越来越多的数据表明并非所有抗抑郁药都会抑制REM睡眠。这些结果也与早期一项研究的解释一致，该研究表明曲唑酮由于其抑制疲软的α-肾上腺素能阻断特性而延长睡眠期间的阴茎勃起。奈法唑酮的α-肾上腺素能阻断活性较低，除了REM睡眠外，不会异常影响阴茎勃起。
