Vogal G, Cohen J, Mullis D, Kensler T, Kaplita S
Sleep Research Laboratory, Inc., Atlanta, GA. USA.
Sleep. 1998;21(1):70-7. doi: 10.1093/sleep/21.1.70.
In previous uncontrolled studies, nefazodone, a new antidepressant drug, increased REM sleep or had no effect on REM sleep. We report a double-blind, placebo-controlled, parallel group study on effects of nefazodone (N) on polysomnographic sleep variables in healthy human volunteers. Nefazodone was administered for 16 consecutive days, and nocturnal sleep, as well as multiple sleep latency test (MSLT), was monitored before, during, and after N administration. We found that N had no effect on any measured REM sleep variable including REM sleep duration, REM density, and nocturnal REM sleep distribution. Nefazodone also had no significant effect on nocturnal total sleep time or NREM variables, but increased daytime alertness measured by the MSLT. Since N is a potent serotonin reuptake blocker, the present findings that N had no effect on REM sleep cast doubt on the hypothesis that antidepressant drugs decrease REM sleep by increasing serotonergic neurotransmission. A review of other relevant work also casts doubt on this hypothesis.
在先前的非对照研究中，新型抗抑郁药奈法唑酮可增加快速眼动睡眠（REM睡眠）或对REM睡眠无影响。我们报告了一项关于奈法唑酮（N）对健康人类志愿者多导睡眠图睡眠变量影响的双盲、安慰剂对照平行组研究。连续16天给予奈法唑酮，并在给药前、给药期间和给药后监测夜间睡眠以及多次睡眠潜伏期试验（MSLT）。我们发现，N对任何测量的REM睡眠变量均无影响，包括REM睡眠时间、REM睡眠密度和夜间REM睡眠分布。奈法唑酮对夜间总睡眠时间或非快速眼动睡眠（NREM）变量也无显著影响，但通过MSLT测量可提高白天的警觉性。由于N是一种强效的5-羟色胺再摄取阻滞剂，目前N对REM睡眠无影响的研究结果对抗抑郁药通过增加5-羟色胺能神经传递来减少REM睡眠这一假说提出了质疑。对其他相关研究的综述也对这一假说提出了质疑。
