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在肺炎克雷伯菌中发现的质粒介导的头孢菌素酶基因（blaLAT-1）的核苷酸序列。

Nucleotide sequence of a plasmid-mediated cephalosporinase gene (blaLAT-1) found in Klebsiella pneumoniae.

作者信息

Tzouvelekis L S, Tzelepi E, Mentis A F

机构信息

Department of Bacteriology, Hellenic Pasteur Institute, Athens, Greece.

出版信息

Antimicrob Agents Chemother. 1994 Sep;38(9):2207-9. doi: 10.1128/AAC.38.9.2207.

DOI:10.1128/AAC.38.9.2207
PMID:7811049
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC284714/
Abstract

The nucleotide sequence of the gene encoding a novel cephalosporinase (LAT-1), carried by a non-self-transferable plasmid from Klebsiella pneumoniae, has been determined. It was found that the sequence shares a high degree of homology with the Citrobacter freundii OS60 ampC structural gene.

摘要

已确定了由肺炎克雷伯菌的一个非自我转移性质粒携带的编码新型头孢菌素酶（LAT-1）的基因的核苷酸序列。发现该序列与弗氏柠檬酸杆菌OS60 ampC结构基因具有高度同源性。

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本文引用的文献

1
Plasmid-mediated AmpC-type beta-lactamase isolated from Klebsiella pneumoniae confers resistance to broad-spectrum beta-lactams, including moxalactam.从肺炎克雷伯菌中分离出的质粒介导的AmpC型β-内酰胺酶可赋予对包括莫西沙星在内的广谱β-内酰胺类抗生素的耐药性。
Antimicrob Agents Chemother. 1993 May;37(5):984-90. doi: 10.1128/AAC.37.5.984.
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Identification of a novel plasmid-mediated beta-lactamase with chromosomal cephalosporinase characteristics from Klebsiella pneumoniae.从肺炎克雷伯菌中鉴定出一种具有染色体头孢菌素酶特性的新型质粒介导的β-内酰胺酶。
J Antimicrob Chemother. 1993 May;31(5):645-54. doi: 10.1093/jac/31.5.645.
3
Cloning and sequence analysis of blaBIL-1, a plasmid-mediated class C beta-lactamase gene in Escherichia coli BS.大肠杆菌BS中质粒介导的C类β-内酰胺酶基因blaBIL-1的克隆与序列分析
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Infection. 1989 Sep-Oct;17(5):316-21. doi: 10.1007/BF01650718.
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Extended-spectrum beta-lactamases.超广谱β-内酰胺酶
Antimicrob Agents Chemother. 1989 Aug;33(8):1131-6. doi: 10.1128/AAC.33.8.1131.
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Function of the conserved triad residues in the class C beta-lactamase from Citrobacter freundii GN346.弗氏柠檬酸杆菌GN346中C类β-内酰胺酶保守三联体残基的功能
FEBS Lett. 1990 Oct 1;271(1-2):243-6. doi: 10.1016/0014-5793(90)80416-g.
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Role of lysine-67 in the active site of class C beta-lactamase from Citrobacter freundii GN346.
Eur J Biochem. 1990 Feb 22;188(1):15-22. doi: 10.1111/j.1432-1033.1990.tb15365.x.