质粒编码的ACC-4，一种来自大肠杆菌的超广谱头孢菌素酶变体。
Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli.
作者信息
Papagiannitsis Costas C, Tzouvelekis Leonidas S, Tzelepi Eva, Miriagou Vivi
机构信息
Laboratory of Bacteriology, Hellenic Pasteur Institute, Vas Sofias 127, Athens, Greece.
出版信息
Antimicrob Agents Chemother. 2007 Oct;51(10):3763-7. doi: 10.1128/AAC.00389-07. Epub 2007 Jul 30.
Abstract
ACC-4, an omega loop mutant (Val(211)-->Gly) of the Hafnia alvei-derived cephalosporinase ACC-1, was encoded by an Escherichia coli plasmid. The genetic environment of bla(ACC-4) shared similarities with plasmidic regions carrying bla(ACC-1). Kinetics of beta-lactam hydrolysis and levels of resistance to beta-lactams showed that ACC-4 was more effective than ACC-1 against expanded-spectrum cephalosporins.
摘要
ACC-4是源自蜂房哈夫尼亚菌的头孢菌素酶ACC-1的一个ω环突变体（Val(211)→Gly），由大肠杆菌质粒编码。bla(ACC-4)的遗传环境与携带bla(ACC-1)的质粒区域具有相似性。β-内酰胺水解动力学和对β-内酰胺的耐药水平表明，ACC-4对超广谱头孢菌素的作用比ACC-1更有效。
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