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SCO-1, a novel plasmid-mediated class A beta-lactamase with carbenicillinase characteristics from Escherichia coli.SCO-1，一种来自大肠杆菌的具有羧苄青霉素酶特性的新型质粒介导的A类β-内酰胺酶。
Antimicrob Agents Chemother. 2007 Jun;51(6):2185-8. doi: 10.1128/AAC.01439-06. Epub 2007 Mar 12.
2
Genetic environment of acquired bla(ACC-1) beta-lactamase gene in Enterobacteriaceae isolates.肠杆菌科分离株中获得性bla(ACC-1)β-内酰胺酶基因的遗传环境
Antimicrob Agents Chemother. 2006 Dec;50(12):4177-81. doi: 10.1128/AAC.00619-06. Epub 2006 Sep 18.
3
Biochemical and molecular characterization of three new variants of AmpC beta-lactamases from Morganella morganii.摩根氏摩根菌AmpCβ-内酰胺酶三种新变体的生化与分子特征
Antimicrob Agents Chemother. 2006 Mar;50(3):962-7. doi: 10.1128/AAC.50.3.962-967.2006.
4
In vivo transfer of plasmid-encoded ACC-1 AmpC from Klebsiella pneumoniae to Escherichia coli in an infant and selection of impermeability to imipenem in K. pneumoniae.婴儿体内肺炎克雷伯菌质粒编码的ACC-1 AmpC向大肠杆菌的转移以及肺炎克雷伯菌对亚胺培南不渗透性的选择
Antimicrob Agents Chemother. 2005 Aug;49(8):3562-5. doi: 10.1128/AAC.49.8.3562-3565.2005.
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beta-Lactamases among extended-spectrum beta-lactamase (ESBL)-resistant Salmonella from poultry, poultry products and human patients in The Netherlands.荷兰家禽、家禽产品及人类患者中对超广谱β-内酰胺酶（ESBL）耐药的沙门氏菌中的β-内酰胺酶
J Antimicrob Chemother. 2005 Jul;56(1):115-21. doi: 10.1093/jac/dki190. Epub 2005 Jun 7.
6
Spread of a Klebsiella pneumoniae strain producing a plasmid-mediated ACC-1 AmpC beta-lactamase in a teaching hospital admitting disabled patients.一株产质粒介导的ACC-1 AmpCβ-内酰胺酶的肺炎克雷伯菌在一家收治残疾患者的教学医院中的传播。
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7
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Escherichia coli producing an ACC-1 class C beta-lactamase isolated in Barcelona, Spain.在西班牙巴塞罗那分离出的产ACC-1类C型β-内酰胺酶的大肠杆菌。
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Molecular epidemiology and characterization of plasmid-encoded beta-lactamases produced by Tunisian clinical isolates of Salmonella enterica serotype Mbandaka resistant to broad-spectrum cephalosporins.突尼斯肠炎沙门氏菌血清型姆班达卡临床分离株产生的质粒编码β-内酰胺酶的分子流行病学及特征分析，该分离株对广谱头孢菌素耐药。
J Clin Microbiol. 2003 Jul;41(7):2940-5. doi: 10.1128/JCM.41.7.2940-2945.2003.
10
Novel plasmid-encoded class C beta-lactamase (MOX-2) in Klebsiella pneumoniae from Greece.来自希腊的肺炎克雷伯菌中新型质粒编码的C类β-内酰胺酶（MOX-2）
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质粒编码的ACC-4，一种来自大肠杆菌的超广谱头孢菌素酶变体。

Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli.

作者信息

Papagiannitsis Costas C, Tzouvelekis Leonidas S, Tzelepi Eva, Miriagou Vivi

机构信息

Laboratory of Bacteriology, Hellenic Pasteur Institute, Vas Sofias 127, Athens, Greece.

出版信息

Antimicrob Agents Chemother. 2007 Oct;51(10):3763-7. doi: 10.1128/AAC.00389-07. Epub 2007 Jul 30.

DOI:10.1128/AAC.00389-07
PMID:17664321
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2043296/
Abstract

ACC-4, an omega loop mutant (Val(211)-->Gly) of the Hafnia alvei-derived cephalosporinase ACC-1, was encoded by an Escherichia coli plasmid. The genetic environment of bla(ACC-4) shared similarities with plasmidic regions carrying bla(ACC-1). Kinetics of beta-lactam hydrolysis and levels of resistance to beta-lactams showed that ACC-4 was more effective than ACC-1 against expanded-spectrum cephalosporins.

摘要

ACC-4是源自蜂房哈夫尼亚菌的头孢菌素酶ACC-1的一个ω环突变体（Val(211)→Gly），由大肠杆菌质粒编码。bla(ACC-4)的遗传环境与携带bla(ACC-1)的质粒区域具有相似性。β-内酰胺水解动力学和对β-内酰胺的耐药水平表明，ACC-4对超广谱头孢菌素的作用比ACC-1更有效。