Hekmatpanah J, Haghighat N, Adams C R
University of Chicago Medical Center, IL 60637.
Alcohol Alcohol. 1994 Sep;29(5):535-47.
To study the effect of alcohol on Purkinje cells and on myelination of the cerebellum of neonate rats, female Sprague-Dawley rats were fed alcohol (ethanol) during their nursing period. The alcohol was given in amounts of 5% or 10% per volume of drinking water. Food and liquids, equal in calories, were distributed among dams receiving alcohol. One group of control rats received similar diet but no alcohol. The results were then compared with those of a second group of controls, receiving no alcohol but having access to unlimited supplies of food and water. Histological examination of pups revealed degenerative changes in Purkinje cells and delayed myelination of the cerebellum.
为研究酒精对新生大鼠浦肯野细胞及小脑髓鞘形成的影响，在哺乳期给雌性斯普拉格-道利大鼠喂食酒精（乙醇）。酒精在饮用水中的含量为体积分数5%或10%。给予摄入酒精的母鼠热量相等的食物和液体。一组对照大鼠接受相似饮食但不摄入酒精。然后将结果与第二组对照大鼠的结果进行比较，第二组对照大鼠不摄入酒精，但可获得无限量的食物和水。对幼鼠的组织学检查显示浦肯野细胞有退行性变化以及小脑髓鞘形成延迟。
