编码鸟氨酸脱羧酶抗酶的人源cDNA的分子克隆与测序
Molecular cloning and sequencing of a human cDNA encoding ornithine decarboxylase antizyme.
作者信息
Tewari D S, Qian Y, Thornton R D, Pieringer J, Taub R, Mochan E, Tewari M
机构信息
Department of Biochemistry/Molecular Biology, Philadelphia College of Osteopathic Medicine, PA 19131.
出版信息
Biochim Biophys Acta. 1994 Dec 14;1209(2):293-5. doi: 10.1016/0167-4838(94)90199-6.
PMID:7811704
Abstract
We report the cloning of a cDNA encoding the human homolog of ornithine decarboxylase antizyme from a human gingival fibroblast cDNA library. The human antizyme is 84% identical to the rat sequence and shows almost no homology to the E. coli antizyme. Northern analysis studies show that this gene is expressed in both human gingival and synovial fibroblasts.
摘要
我们报道了从人牙龈成纤维细胞cDNA文库中克隆出编码鸟氨酸脱羧酶抗酶人同源物的cDNA。人抗酶与大鼠序列有84%的同一性，且与大肠杆菌抗酶几乎没有同源性。Northern分析研究表明，该基因在人牙龈成纤维细胞和滑膜成纤维细胞中均有表达。
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