Aste H, Picasso M, Allegretti A, Conio M
Gastrointestinal Service, Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy.
Cancer Detect Prev. 1994;18(5):343-8.
Familial aggregation of colorectal cancer occurs even among sporadic cases that are not part of defined genetic syndromes. First-degree relatives of patients with "sporadic" colorectal cancer have a three- to fourfold increased risk of the same cancer. The aim of the present study is to investigate the relationship between a first-degree family history of colorectal cancer and the pathological and clinical features of the tumor (site, Dukes' stage, age at diagnosis, sex, and patient survival). Four hundred and sixty-one patients with colorectal cancer were evaluated (250 males and 211 females) and information obtained on their family history of cancer. Sex, age, and stage of disease were the only parameters that correlated significantly with survival. No relationship between family history of colorectal cancer and the prognostic variables was observed.
即使在不属于特定遗传综合征的散发性病例中，结直肠癌也会出现家族聚集现象。“散发性”结直肠癌患者的一级亲属患同一种癌症的风险增加三到四倍。本研究的目的是调查结直肠癌一级家族史与肿瘤的病理和临床特征（部位、杜克分期、诊断年龄、性别和患者生存率）之间的关系。对461例结直肠癌患者（250例男性和211例女性）进行了评估，并获取了他们的癌症家族史信息。性别、年龄和疾病分期是与生存率显著相关的唯一参数。未观察到结直肠癌家族史与预后变量之间存在关联。
