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Typing of hepatitis C virus isolates and characterization of new subtypes using a line probe assay.使用线性探针分析对丙型肝炎病毒分离株进行分型及新亚型的特征分析。
J Gen Virol. 1993 Jun;74 ( Pt 6):1093-102. doi: 10.1099/0022-1317-74-6-1093.
2
Sequence variability in the 5' non-coding region of hepatitis C virus: identification of a new virus type and restrictions on sequence diversity.丙型肝炎病毒5'非编码区的序列变异性：一种新病毒类型的鉴定及序列多样性的限制
J Gen Virol. 1993 Apr;74 ( Pt 4):661-8. doi: 10.1099/0022-1317-74-4-661.
3
Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region.通过对NS-5区域进行系统发育分析，将丙型肝炎病毒分为六个主要基因型和一系列亚型。
J Gen Virol. 1993 Nov;74 ( Pt 11):2391-9. doi: 10.1099/0022-1317-74-11-2391.
4
Hepatitis C virus variants from Nepal with novel genotypes and their classification into the third major group.来自尼泊尔的具有新型基因型的丙型肝炎病毒变体及其被归入第三大主要组。
J Gen Virol. 1994 Apr;75 ( Pt 4):931-6. doi: 10.1099/0022-1317-75-4-931.
5
Sequence analysis of the 5' untranslated region in isolates of at least four genotypes of hepatitis C virus in The Netherlands.荷兰至少四种丙型肝炎病毒基因型分离株5'非翻译区的序列分析。
J Clin Microbiol. 1994 Feb;32(2):306-10. doi: 10.1128/jcm.32.2.306-310.1994.
6
The entire nucleotide sequence and classification of a hepatitis C virus isolate of a novel genotype from an Indonesian patient with chronic liver disease.一名患有慢性肝病的印度尼西亚患者的新型基因型丙型肝炎病毒分离株的全核苷酸序列及分类
J Gen Virol. 1994 Mar;75 ( Pt 3):629-35. doi: 10.1099/0022-1317-75-3-629.
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Prevalence of hepatitis C virus genotypes in Italy.意大利丙型肝炎病毒基因型的流行情况。
J Clin Microbiol. 1994 Jan;32(1):232-4. doi: 10.1128/jcm.32.1.232-234.1994.
8
Identification of hepatitis C virus subtype 3b (HCV-3b) among Japanese patients with liver diseases using highly efficient primers for reverse transcription-polymerase chain reaction.使用高效逆转录-聚合酶链反应引物在日本肝病患者中鉴定丙型肝炎病毒3b型（HCV-3b）
Microbiol Immunol. 1994;38(2):159-63. doi: 10.1111/j.1348-0421.1994.tb01759.x.
9
Analysis of the core and E1 envelope region sequences of a novel variant of hepatitis C virus obtained in Indonesia.
Arch Virol. 1994;136(1-2):53-62. doi: 10.1007/BF01538816.
10
Primary structural comparison of RNA-dependent polymerases from plant, animal and bacterial viruses.植物、动物和细菌病毒的RNA依赖性聚合酶的一级结构比较。
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泰国清迈健康献血者和吸毒者中丙型肝炎病毒分离株的分析。

Analysis of hepatitis C virus isolates among healthy blood donors and drug addicts in Chiang Mai, Thailand.

作者信息

Apichartpiyakul C, Chittivudikarn C, Miyajima H, Homma M, Hotta H

机构信息

Department of Microbiology, Faculty of Medicine, Chiang Mai University, Thailand.

出版信息

J Clin Microbiol. 1994 Sep;32(9):2276-9. doi: 10.1128/jcm.32.9.2276-2279.1994.

DOI:10.1128/jcm.32.9.2276-2279.1994
PMID:7814558
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC263982/
Abstract

Hepatitis C virus (HCV) isolates obtained from 25 anti-HCV antibody-positive healthy blood donors and 29 drug addicts in Chiang Mai, Thailand, were analyzed. HCV RNA was detected in 23 blood donor samples (92%) and 24 drug addict blood samples (83%) by PCR for a portion of the NS5 region. Subtype analysis revealed that HCV type 3a (HCV-3a) was the prevailing subtype (30%), which was followed in prevalence by HCV-1a (21%), -1b (13%), -3b (13%), and -6a (2%). Six (13%) of the 47 isolates showed low sequence similarities with known types and subtypes. The sequence variants could be grouped into four branches in a molecular evolutionary phylogenetic tree.

摘要

对从泰国清迈25名抗丙型肝炎病毒（HCV）抗体呈阳性的健康献血者和29名吸毒者中获得的HCV分离株进行了分析。通过针对NS5区域一部分的PCR检测，在23份献血者样本（92%）和24份吸毒者血液样本（83%）中检测到了HCV RNA。亚型分析显示，HCV 3a型（HCV-3a）是主要亚型（30%），其次是HCV-1a（21%）、-1b（13%）、-3b（13%）和-6a（2%）。47株分离株中有6株（13%）与已知类型和亚型的序列相似性较低。在分子进化系统发育树中，序列变异体可分为四个分支。