Masoro E J, Shimokawa I, Higami Y, McMahan C A, Yu B P
Department of Physiology, University of Texas Health Science Center at San Antonio.
J Gerontol A Biol Sci Med Sci. 1995 Jan;50A(1):B48-53. doi: 10.1093/gerona/50a.1.b48.
Long-term dietary restriction programs which retard aging processes in rodents usually involve meal eating rather than the nibbling pattern of food intake of ad libitum fed rodents. Thus, the possibility arises that the antiaging action may at least in part result from an altered temporal pattern of food intake. This possibility was investigated using male F344 rats maintained on the following dietary regimens: Group A rats fed ad libitum; Group B rats fed 60% the ad libitum intake in a single meal at 1500 h; Group B-2 rats fed 60% of the ad libitum intake in two meals (0700 h and 1500 h). The diurnal pattern of plasma corticosterone concentration differed among the groups as did that of the plasma glucose concentration. The median length of life and age of tenth percentile survivors were similar for Group B and B-2 rats and much greater than those for Group A rats. Both modes of dietary restriction influenced age-associated disease processes in a similar fashion. Thus, although the temporal pattern of food intake influenced circadian rhythms of food-restricted rats, it did not significantly affect the antiaging action.
长期的饮食限制方案能够延缓啮齿动物的衰老过程，这类方案通常采用定时进食，而非随意进食的啮齿动物那种断断续续的进食方式。因此，有可能抗老化作用至少部分是由食物摄入时间模式的改变导致的。我们使用雄性F344大鼠，通过以下饮食方案来研究这种可能性：A组大鼠随意进食；B组大鼠在15:00时一次性进食随意摄入量的60%；B-2组大鼠分两餐（07:00时和15:00时）进食随意摄入量的60%。各组之间血浆皮质酮浓度的昼夜模式以及血浆葡萄糖浓度的昼夜模式均有所不同。B组和B-2组大鼠的中位寿命和第十百分位幸存者的年龄相似，且远大于A组大鼠。两种饮食限制模式以相似的方式影响与年龄相关的疾病进程。因此，尽管食物摄入的时间模式影响了饮食受限大鼠的昼夜节律，但并未显著影响其抗老化作用。
