Froy Oren
Institute of Biochemistry, Food Science and Nutrition, Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, P.O. Box 12, 76100 Rehovot, Israel.
ISRN Obes. 2012 Nov 18;2012:437198. doi: 10.5402/2012/437198. eCollection 2012.
Obesity has become a serious public health problem and a major risk factor for the development of illnesses, such as insulin resistance and hypertension. Attempts to understand the causes of obesity and develop new therapeutic strategies have mostly focused on caloric intake and energy expenditure. Recent studies have shown that the circadian clock controls energy homeostasis by regulating the circadian expression and/or activity of enzymes, hormones, and transport systems involved in metabolism. Moreover, disruption of circadian rhythms leads to obesity and metabolic disorders. Therefore, it is plausible that resetting of the circadian clock can be used as a new approach to attenuate obesity. Feeding regimens, such as restricted feeding (RF), calorie restriction (CR), and intermittent fasting (IF), provide a time cue and reset the circadian clock and lead to better health. In contrast, high-fat (HF) diet leads to disrupted circadian expression of metabolic factors and obesity. This paper focuses on circadian rhythms and their link to obesity.
肥胖已成为一个严重的公共卫生问题，也是诸如胰岛素抵抗和高血压等疾病发展的主要风险因素。试图了解肥胖原因并开发新治疗策略的研究大多集中在热量摄入和能量消耗上。最近的研究表明，生物钟通过调节参与新陈代谢的酶、激素和转运系统的昼夜节律表达和/或活性来控制能量平衡。此外，昼夜节律紊乱会导致肥胖和代谢紊乱。因此，重置生物钟可作为减轻肥胖的一种新方法，这似乎是合理的。进食方案，如限时进食（RF）、热量限制（CR）和间歇性禁食（IF），提供了一个时间线索，重置了生物钟，并带来更好的健康状况。相比之下，高脂（HF）饮食会导致代谢因子的昼夜节律表达紊乱和肥胖。本文重点关注昼夜节律及其与肥胖的联系。
