Persutte W H, Lenke R R
Department of Obstetrics and Gynaecology, University of Colorado Health Sciences Center, Denver 80262.
Lancet. 1995 Jan 14;345(8942):96-7. doi: 10.1016/s0140-6736(95)90064-0.
We investigated outcome in patients whose amniotic-fluid-cell samples showed unexplained growth failure in culture. 32 of 7872 amniocentesis samples were classified as unexplained growth failures. 10 women did not have repeat cytogenetic testing, but among their pregnancies there were 4 abnormal outcomes (1 fetal bladder-outlet obstruction, 2 stillbirths, and 1 acardiac twin). Of the 22 patients who had repeat karyotypic analysis, 18 had normal fetal karyotypes. However, 4 fetuses were aneuploid (2 trisomy 21, 1 trisomy 13, and 1 Pallister-Killian syndrome).
我们对羊水细胞样本在培养中显示原因不明生长失败的患者的结局进行了调查。7872例羊膜腔穿刺样本中有32例被归类为原因不明的生长失败。10名女性未进行重复细胞遗传学检测，但在她们的妊娠中有4例异常结局（1例胎儿膀胱出口梗阻、2例死产和1例无心双胎）。在进行重复核型分析的22例患者中，18例胎儿核型正常。然而，有4例胎儿为非整倍体（2例21三体、1例13三体和1例帕利斯特-基利安综合征）。
